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KMID : 0043319900130040355
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Archives of Pharmacal Research
1990 Volume.13 No. 4 p.355 ~ p.358
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Effects of Brazilin on Glucose Metabolism in Primary Cultured Rat Hepatocytes
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Moon CK
Lee SH/Chung JH/Kim SG/Chung MK/Moon CH
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Abstract
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In order to investigate the cellular mechanisms of hypoglycemic action of brazilin, hepatocyte monolayer culture was introduced and, glycogen synthesis rate and insulin binding were measured as parameters. Glycogen synthesis and insulin sensitivity were remarkably augmented by the treatment of brazilin. Brazilin slightly increased insulin binding. Scatchard analysis revealed that this increase in insulin binding was not due to increase in the binding capacity but in binding affinity. These results suggest that the augmentation of hepatic glycogenesis and insulin sensitivity by brazilin may play an important role in the improvement of hyperglycemia.
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KEYWORD
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